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GLP-1 Agonists Are Still Going Strong

GLP-1 Agonists Are Still Going Strong

Consumers are flooded with weight loss options—from exercise apps to intermittent fasting to ketogenic diets. But nothing is making waves like GLP-1s.

GLP-1 agonists, such as Ozempic and Wegovy, are transforming weight management. The results are impressive—but they don’t come without challenges.

Digestive Challenges with GLP-1 Agonists

Up to 70% of GLP-1 users struggle with GI discomfort, including nausea, vomiting and diarrhea. Meanwhile, 86% fail to meet protein needs, risking muscle loss, slowed metabolism, and fatigue.

The result? Poor adherence, consumer dropout and stalled outcomes. For formulators, this presents a significant opportunity to provide solutions that help consumers stay on track.

GLP-1 Market Size

Today, roughly six percent of U.S. adults use GLP-1 drugs, another 12% have tried them and nearly 1/3 are aware of them.

It’s no surprise that by 2035, the GLP-1 market is projected to triple in size—jumping from $4.1 billion to $13 billion.

As millions of consumers embrace GLP-1s, the need for support solutions that keep them comfortable, nourished and on track will skyrocket.

Enter the DigeSEB® line.

The Gold Standard in Digestive Enzymes

For more than three decades, DigeSEB® has set the gold standard in digestive support. The DigeSEB® line is expertly formulated to support optimal digestion and nutrient absorption, helping consumers digest food properly and avoid discomfort.
It’s the foundation every GLP-1 companion product needs.

  • Relief from gas, bloating & abdominal discomfort
  • Healthy bowel movements & regularity
  • Management of indigestion
  • Efficient nutrient absorption
  • Digestion of fats, carbs, dairy & proteins
  • Release of nutrients trapped in difficult-to-digest plant cell walls
  • Breakdown of raffinose family oligosaccharides (RFOs)

Clean-label, Non-GMO Project verified, Halal and Kosher-certified, DigeSEB® supports consumers in remaining comfortable and nourished.

Specific Challenges. Targeted Solutions.

DigeSEB Super™
Next-Level Digestive Support

When food intake drops and digestion slows, every bite counts. DigeSEB Super™ is expertly formulated to help consumers extract maximum nutrition without GI discomfort.

A recently published study showed DigeSEB Super™ increased the release of sugars, amino acids and free fatty acids by up to 69% within one hour, demonstrating improved digestion of carbohydrates, proteins and fats.

It’s the next-level digestive support consumers need to feel better and stick with GLP-1s. 

DigeSEB Sport™
Support Muscle. Fuel Energy.

Consumers on GLP-1s often fall short on protein, risking muscle loss and fatigue. DigeSEB Sport™ is specifically designed to help them get the most out of every gram of protein.

  • Greater rate of BCAA & essential amino acid release & absorption
  • Microbiome diversity & gut health
  • Production of postbiotics linked to athletic performance, muscle recovery & energy levels

 

DigeSEB Sport™ is the perfect add-on to protein and sports nutrition products, helping consumers stay strong, energized and engaged during and after their GLP-1 journey.

The Bottom Line

GLP-1 therapy is a breakthrough, but it isn’t a silver bullet. Without support, consumers face real risks: GI discomfort, nutrient gaps and muscle loss.

Formulators who incorporate DigeSEB Super™ and DigeSEB Sport™
can deliver the targeted, research-backed support that consumers need.

The payoff is simple: happier, healthier consumers who stay the course—and products that win in a rapidly expanding market.

The GLP-1 era is here. Ensure your products rise to meet the challenge with the DigeSEB Super™ and DigeSEB Sport™.

Let’s Connect at Supplyside Global

Our team of enzyme and probiotic experts is looking forward to meeting you at SupplySide Global. Schedule a meeting in advance or stop by Booth #3465 during the show, October 27-30. Let’s discuss how our science-backed branded ingredients can make your formulations shine!

SOURCES

  1. GLP-1 side effects only one factor driving patient discontinuation rates. BioSpace. (2025, March 10).
  2. Enhancing GLP-1 benefits with protein intake. PURIS. (2025, February 11).
  3. Future Market Insights. (2025, July 16). GLP-1 nutritional support market size & share 2025-2035. Future Market Insights.
  4. Rathi, A., Potale, S., Vaze, R., Muley, A. B., & Jadhav, S. (2024, April 25). In vitro simulated study of macronutrient digestion in complex food using digestive enzyme supplement. Heliyon.
  5. Rathi, A., Gaonkar, T., Dhar, D. et al. Metabolomics and gut metagenomics profile of the healthy adults on consumption of whey protein supplemented with enzymes-probiotics blend. Discov Appl Sci 6, 147 (2024).
  6. Rathi A, Gaonkar T, Dhar D, Kallapura G, Jadhav S. Study of amino acids absorption and gut microbiome on consumption of pea protein blended with enzymes-probiotics supplement. Front Nutr. 2024 Jan 23;11:1307734. doi: 10.3389/fnut.2024.1307734. PMID: 38321993; PMCID: PMC10844538.